1. Recognize the signs of an opioid overdose:

• Person is unresponsive or unconscious

• Slow, shallow, or no breathing

• Blue or gray lips and fingertips

• Gurgling or choking sounds

• Pinpoint pupils

2. Call 911 immediately.
Even if naloxone is given, emergency medical help is still necessary.
3. Lay the person on their back.
Tilt their head back slightly to open the airway.
4. Administer the naloxone nasal spray:

• Hold the spray with your thumb on the bottom plunger and two fingers on the nozzle.

• Gently insert the tip of the nozzle into one nostril until your fingers are against the bottom of their nose.

• Press the plunger firmly to release the full dose into their nose.

5. Wait and monitor.

• Naloxone should start working within 2–3 minutes.

• If the person does not respond or starts to relapse into overdose symptoms, give another dose in the other nostril every 2–3 minutes, using a new device each time.

6. Perform rescue breathing or CPR if trained and needed.
7. Stay with the person.
They may wake up confused, agitated, or sick. Help keep them calm and safe until medical help arrives.

Important Notes:

• Naloxone is safe, non-addictive, and does not affect someone who hasn’t used opioids.

• Store naloxone at room temperature and check expiration dates regularly.